Chitosan-Iron Oxide Nanoparticle Preparation and Performance as a Lipid-Lowering Agent in Serum Patients with Nephrotic Syndrome
DOI:
https://doi.org/10.22317/imj.v7i3.1253Abstract
Objective: The main objectives of this study was to Prepare and study the structural features of chitosan/iron oxide nanoparticles CS-FeO NPs and to examine the applications of chitosan nanoparticles as a lipid-lowering agent in children with nephrotic syndrome
Method: The preparation processes for nanoparticles are described in depth. Chitosan nanoparticle applications are shown. X-ray diffraction patterns (XRD) indicated that the magnetic Fe3O4 nanoparticles were pure Fe3O4 with a spinel structure and the coating of chitosan did not result in a phase change.
Results: The coating of CTS onto the Fe3O4 nanoparticles was also demonstrated by the measurement of Fourier transform infrared (FTIR) spectra. Magnetic measurement revealed that the saturated magnetization of the Fe3O4–chitosan nanoparticles reached +18.3 mV and the nanoparticles showed the characteristics of superparamagnetic.
Conclusion: Magnetic Fe3O4–chitosan nanoparticles were prepared successfully by the covalent binding of CTS on the Fe3O4 nanoparticles. These microspheres was apply to the magnetic-field-assisted lipid lowering processes.
References
Lloyd-Parry, O., Downing, C., Aleisaei, E., Jones, C. and Coward, K., 2018. Nanomedicine applications in women’s health: state of the art. International Journal Of Nanomedicine, pp. 1963–1983.
Alwan, S., Al-Saeed, M. and Abid, H., 2021. Safety assessment and biochemical evaluation of the effect of biogenic silver nanoparticles (using bark extract of C. zeylanicum) on Rattus norvegicus rats. Baghdad Journal of Biochemistry and Applied Biological Sciences, 2(03), pp. 133–145.
Raju, G.S.R., Benton, L., Pavitra, E. and Yu, J.S., 2015. Multifunctional nanoparticles: recent progress in cancer therapeutics. Chemical
Communications, 51(68), pp. 13248–13259.
Nam, S.M., Seo, J.S., Nahm, S.S. and Chang, B.J., 2019. Effects of ascorbic acid on osteopontin expression and axonal myelination in the
developing cerebellum of lead-exposed rat pups. International Journal of Environmental Research and Public Health, 16(6), p. 983.
Bharathi, D., Ranjithkumar, R., Chandarshekar, B. and Bhuvaneshwari, V., 2019. Preparation of chitosan-coated zinc oxide nanocomposite for enhanced antibacterial and photocatalytic activity: as a bionanocomposite. International Journal of Biological Macromolecules, 129, pp. 989–996.
Zhu, N., Ji, H., Yu, P., Niu, J., Farooq, M.U., Akram, M.W., Udego, I.O., Li, H. and Niu, X., 2018. Surface modification of magnetic iron oxide nanoparticles. Nanomaterials, 8(10), p. 810.
Rabea, E.I., Badawy, M.E.T., Stevens, C.V., Smagghe, G. and Steurbaut, W., 2003. Chitosan as antimicrobial agent: applications and mode of action. Biomacromolecules, 4(6), pp. 1457–1465.
Sun, S.N., Wei, C., Zhu, Z.Z., Hou, Y.L., Venkatraman, S.S. and Xu, Z.C., 2014. Magnetic iron oxide nanoparticles: Synthesis and surface coating techniques for biomedical applications. Chinese Physics B, 23(3), p. 037503.
Abd El-Ghaffar, M.A. and Hashem, M.S., 2010. Chitosan and its amino acids condensation adducts as reactive natural polymer supports for cellulase immobilization. Carbohydrate Polymers, 81(3), pp. 507–516.
El‐Ghaffar, M.A. and Hashem, M.S., 2009. Immobilization of α‐amylase onto chitosan and its amino acid condensation adducts. Journal of Applied Polymer Science, 112(2), pp. 805–814.
Eslami, S., Ebrahimzadeh, M.A. and Biparva, P., 2018. Green synthesis of safe zero valent iron nanoparticles by Myrtus communis leaf extract as an effective agent for reducing excessive iron in iron-overloaded mice, a thalassemia model. RSC Advances, 8(46), pp. 26144–26155.
Vasantharaj, S., Sripriya, N., Shanmugavel, M., Manikandan, E., Gnanamani, A. and Senthilkumar, P., 2018. Surface active gold nanoparticles biosynthesis by new approach for bionanocatalytic activity. Journal of Photochemistry and Photobiology B: Biology, 179, pp. 119–125.
Rajiv, P., Bavadharani, B., Kumar, M.N. and Vanathi, P., 2017. Synthesis and characterization of biogenic iron oxide nanoparticles using green chemistry approach and evaluating their biological activities. Biocatalysis and Agricultural Biotechnology, 12, pp. 45–49.
Shi, S.F., Jia, J.F., Guo, X.K., Zhao, Y.P., Chen, D.S., Guo, Y.Y., Cheng, T. and Zhang, X.L., 2012. Biocompatibility of chitosan-coated iron oxide nanoparticles with osteoblast cells. International Journal of Nanomedicine, pp. 5593–5602.