Neopterin, interleukin-6, and non HDL-C as predictors for cardiac disease among type 2 diabetic women with and without renal complications

Abstract

Objective To estimate serum concentration of pro-inflammatory marker interleukin-6 (IL-6) and cell-mediated immunity marker neopterin and their relation with non-HDL-C as predictors for cardiovascular risks in type 2 diabetes mellitus patients with and without renal complications. To estimate the serum levels of IL-6 and neopterin in patients groups and compare their levels with healthy control group and study their correlations with other biochemical parameters.
Methods The circulating neopterin and IL-6 levels were measured in 45 type 2 diabetic women with renal failure (ESRD), 50 women in T2DM without renal failure and 55 healthy control women without a known family history of diabetes with matched age and body mass index (age range 46–70 years). They were attending at Al-Kadhmia Teaching Hospital in Baghdad during the period from March to September 2014.
The BIOSOURCE ELISA kit was used to measure S. IL-6 and neopterin, and enzymatic methods are used for blood sugar, urea, creatinine, and
lipid profile measurements.
Results A significant increase was found in serum levels of IL-6 and neopterin between the two diabetic groups when compared with healthy control group (P < 0.05). IL-6 levels were positively correlated with neopterin, triglyceride and non-HDL-C (P < 0.05), and serum neopterin was correlated significantly with non-HDL-C, eGFR (P < 0.001) levels in ESRD and type 2 diabetic women.
Conclusion Serum neopterin, IL-6 and non-HDL-C levels directly contribute to the development of cardiac risk factors in type 2 diabetic women with renal failure complication.